Where exactly do these polygenic scores come from?
I ask because such a result could easily be circular, depending on the methodology — if one did PGS analysis using all of modern Europe, for example, the fact that there are more introvertsin the dataset in Finland would itself tend to cause more of their genes to be classified as introverted. That could happen even if the explanation were actually cultural. Of course, that circularity could be headed off by creating PG scores based on, for example, only a British population. But the method used seems very important and the perfect-correlation map makes me suspicious.
Good question. It’s based on a sample of Americans of European descent called Million Veteran Program. So I do not think it’s affected the by the issue you have mentioned. I have added the GWAS citation to the blog post.
Where exactly do these polygenic scores come from?
I ask because such a result could easily be circular, depending on the methodology — if one did PGS analysis using all of modern Europe, for example, the fact that there are more introvertsin the dataset in Finland would itself tend to cause more of their genes to be classified as introverted. That could happen even if the explanation were actually cultural. Of course, that circularity could be headed off by creating PG scores based on, for example, only a British population. But the method used seems very important and the perfect-correlation map makes me suspicious.
What is the method used for these?
Good question. It’s based on a sample of Americans of European descent called Million Veteran Program. So I do not think it’s affected the by the issue you have mentioned. I have added the GWAS citation to the blog post.